AAK1AP2 Associated Kinase 1 (activating protein 2, AP2)
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LX9211 is a selective inhibitor of AAK1 (adapter-associated kinase), which in preclinical studies demonstrated significant reduction in pain response in a series of pain models and was well-tolerated at and above efficacious doses in animals.
miRNA Function Putative targets Reference miR-17-92 Down-regulated in IRF9, RAB10, [72] imatinib treated TXNIP, TET2 CML cells miR-21 Antisense TXPAN2, LUM, [73] inhibition leads SUZ12, MSH2, to inhibition of PDZD2 migration and cell growth and induces apoptosis miR-203 Methylated in AML, RTKN2, AAK1, [74] CML, ALL, CLL.
And they identified the 15q26.2 region as well as the gene AAK1 related to the previously observed PD susceptibility gene, GAK as areas that would benefit from further examination.