The association between a dietary pattern resulting in higher NEAP and progression of kidney disease (time to ESRD or doubling of serum creatinine) has been investigated in 632 participants in the AASK
trial, but no definite conclusion could be attained.
Greene et al., "Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK
trial," The Journal of the American Medical Association, vol.
The 1094 randomized participants in the AASK
study were self-identified African Americans with hypertension between 18 and 70 years of age, with initial GFR between 20 and 65mL/min per 1.73 [m.sup.2] and with no other identified causes of renal insufficiency.
And results from AASK
(African-American Study of Kidney Disease and Hypertension) showed that intensive blood pressure reduction produced no improvement in the outcome of lost renal function, end-stage renal disease, or death compared with conventional blood pressure control (JAMA 2002;288:2421-31).
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Es importante senalar que en este estudio los pacientes tenian una PA basal de 130/80 mmHg, y existio una diferencia importante en relacion a los resultados del estudio AASK
(27), estudio en el que pese a que existio una mayor reduccion de la PA (5 mmHg del AASK
versus 4 mmHg del MDRD), no se reporto un beneficio significativo en la progresion de la enfermedad renal.
Appel of Johns Hopkins University, Baltimore, and his associates in the AASK
(African-American Study of Kidney Disease and Hypertension) Collaborative Research Group.
On average, a lower blood pressure goal was no better than the standard blood pressure goal at slowing progression of kidney disease among African-Americans who had chronic kidney disease resulting from high blood pressure, according to results of the African-American Study of Kidney Disease and Hypertension (AASK
), the largest and longest study of chronic kidney disease (CKD) in African-Americans.
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To understand the success of the African American Study of Kidney Disease and Hypertension (AASK
) in protocol adherence and subject retention, the authors examined why some participants came for their protocol visits and why others had barriers to the visit schedule.
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