AAUCMBAverage Area under the Curve Minus Baseline
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The primary endpoint was the proportion of patients with a viral load <400 copies/ml at 48 weeks with secondary endpoints being CD4 cell count rise, tolerability and clinical and laboratory toxicity, viral load <50 copies/ml, and the mean time-averaged change under the curve minus baseline (AAUCMB) in HIV-RNA.
The primary objective was to examine the AAUCMB for non-inferiority of the two boosted fosamprenavir arms to boosted lopinavir by intention-to-treat (ITT) analysis and 320 patients were enrolled.