Furthermore, catalase, ABAH, and methionine clearly inhibited DNA halogenation.
Catalase, ABAH, and methionine each inhibited the increased apoptosis caused by BT, and catalase and ABAH inhibited increases in HOCl and *OH.
For experiments with ABAH (MPO inhibitor) and methionine (HOG scavenger), HL-60 cells were preincubated with RPMI 1640/10% FCS containing 1001.
For experiments with ABAH or methionine, cells were pretreated and exposed as described above.
9] Nonstandard abbreviations: CGD, chronic granulomatous disease; ROI, reactive oxygen intermediate; MPO, myeloperoxidase; DHR, cytometric dihydrorhodamine 123; SHA, salicylhydroxamic acid; ABAH
, 4-aminobenzoylhydrazide; PMA, phorbol-myristate-acetate; mAb, monoclonal antibody; LCL, lucigenin-enhanced chemiluminescence.