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ABCA1ATP (Adenosine Triphosphate) Binding Cassette Transporter A1
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Finally, the novel mutation (P85L) in ABCA1 was identified in one family with low HDL but was not detected in over 400 chromosomes of healthy subjects [104].
As 24(S)OH-cholesterol is a high affinity ligand for LXRa and LXR^, this sterol enhances expression of ABCA1 to upregulate cholesterol efflux.
Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice.
The genotyping of ABCA1 C-565T polymorphism was conducted using the polymerase chain reaction (PCR) followed by restriction fragments length polymorphism analysis.
Depletion of Rab8 in foam cell inhibits cholesterol efflux to apoA-I in part by the reduction of ABCA1 level at the PM [46].
The Western blot showed that RM-1-conditioned medium induced LXR[alpha] activation with increasing the expression of the LXR target gene ABCG1 and ABCA1, while not affecting the expression of LXR[alpha] in DCs.
ATP-binding cassette transporter A1 (ABCA1) translocates cholesterol to the cell surface, where they appear to form lipid domains that interact with amphipathic ahelixes in apolipoproteins.
Lieser et al., "ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism," Gastroenterology, vol.
During lipid metabolism, (1) TMAO significantly increases the expression of ABCA1 and ABCG1 in the liver which helps cholesterol efflux to apoA1 as the cholesterol acceptor; (2) TMAO in the gut also markedly reduces the mRNA expression of NPC1L1, which transports cholesterol into the enterocyte from the gut lumen; (3) TMAO reduces the bile acid pool in the liver, which is associated with the classic RCT by reducing synthetic enzymes CYP7A1 and CYP27A1; and (4) TMAO also reduces the expression of ABCG5/8 in the TICE pathway.
The interaction between apoA-I and surface receptors in peripheral tissues, namely, ATP binding cassette A1 (ABCA1) transporters and SRB1, is responsible for cholesterol transportation [41], and once filled, HDL delivers cholesterol into the liver [41].
Genetic studies in the HDLMP with PCV and AMD have identified susceptibility single nucleotide polymorphisms (SNPs) in multiple genes, including rs3764261/rs2303790 in CETP, rs493258/rs10468017 in LIPC, rs12678919 in LPL, rs1883025 in ABCA1, and rs57137919 in ABCG1.
The results indicated that LXR[alpha] down regulated PPAR[alpha], PPARI3, ABCA1, LPL, ApoE genes after 48 h post-pLenti-03 viruses' infection.