The trial achieved its primary endpoint with the combination of ADCETRIS plus AVD resulting in a statistically significant improvement in modified PFS versus the control arm of ABVD
as assessed by an Independent Review Facility (IRF) (p-value=0.
Variaveis % N % resposta Grupo Etario 99,7 60-69 anos 115 36,5 70-79 anos 106 33,7 [greater than or equal to] 80 anos 94 29,8 Sexo 100,0 Masculino 143 45,3 Feminino 173 54,7 Hospitalizacao 99,4 Sim 237 75,5 Nao 77 24,5 Capacidade funcional 97,2 Independente 130 42,3 Dependente ABVD
51 16,6 Dependente AIVD 126 41,1 Auto percepcao de saude 95,9 Positiva 127 41,9 Negativa 176 58,1 Fragilidade 90,5 Fragil 68 23,8 Nao fragil 218 76,2 ABVD
, Atividades Basicas da Vida Diaria; AIVD, Atividades Instrumentais da Vida Diaria.
Chemotherapy of advanced Hodgkin's disease with MOPP, ABVD
, or MOPP alternating with ABVD
Patient number 2 presented a stable disease; ABVD
chemotherapy was discontinued after the second cycle as the patient refused to continue because of adverse effects.
Standard therapeutic guidelines in HL are promoting the anthracyclin-containing regimen ABVD
as front line therapy in patients with stage II disease and unfavourable prognostic factors .
As only half cycle of ABVD
was administered, we considered the patient refractory due to his rapidly worsening clinical condition; therefore we decided to change to salvage therapy.
In clinical trials when brentuximab was combined with ABVD
, up to 40% of patients were noted to have pulmonary toxicity, leading to a FDA "black box" warning .
On a repeated PET/CT after his sixth cycle of ABVD
, the sigmoid mass was stable at 7.
She was treated with the standard ABVD
regime (Adriamycin, bleomycin, vinblastine, dacarbazine) and achieved remission for 11 years until she presented to us again with a mass in the neck during pregnancy.
Leve: personas con incapacidad para efectuar AIVD, con necesidad de ayuda siempre o casi siempre para efectuar una ABVD
y personas con necesidad de ayuda siempre o casi siempre para efectuar dos AIVD.
For chemotherapy ABVD
(Adriamycin, Bleomycin, Vinblastine, Deticene) was used in 32 patients, ABVD
+ COPP (Cyclophosphamid, Vincristine, Procarbazine, Prednisone) was used in 3 patients, OPPA (Vincristine, Prednisone, Procarbazine, Adriamycin) + COPP was used in 2 patients, COPP+ABV was used in 3 patients and ARA-C/VP-16 + COPP/ABV + CHOP (Cyclophosphamid, Adriamycin, Vincristine, Prednisone) was used in 1 patient.
chemotherapy protocol (adriamycin, bleomycin, vinblastine, and dacarbazine, once every 2 weeks) was begun with the patient.