ACOSOGAmerican College of Surgeons Oncology Group
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More recently, following the results of randomized clinical trials such as the International Breast Cancer Study Group 23-01 (IBCSG 23-01) (24) and ACOSOG Z0011 (4, 5), the role of LNRhas been called into question.
Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: The ACOSOG Z1071 (Alliance) Clinical Trial.
Cox et al., "A Phase II Trial Exploring the Success of Cryoablation Therapy in the Treatment of Invasive Breast Carcinoma: Results from ACOSOG (Alliance) Z1072," Annals of Surgical Oncology, vol.
ACOSOG Z0011 excluded patients with matted nodes and gross ECE but had no specific policy regarding microscopic ECE.
Therefore, she and her colleagues will evaluate the 40 biomarkers in pre-and postresection serum samples from patients in the ACOSOG (American College of Surgeons Oncology Group) Z4031 trial.
The ACOSOG Z05031 trial planned to enrol 93 patients [12], but halted accrual at 89 patients because 96%of patients experienced all-attribute grade 3-4 toxicity.
Prospective studies are ongoing to evaluate the prognostic significance of micrometastasis (IBCSG 23-01 trial, ACOSOG Z0010 trial).
Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG ZOO 11 (Alliance) Randomized Clinical Trial.
Confirming that there was no positive lymph node both in mediastinum and hilum through presection sampling, the randomized trial ACOSOG Z0030 concluded that systematic mediastinal lymph node dissection could not improve survival in patients with early-stage NSCLC.[sup][22] Moreover, for early-stage NSCLC patients treated with limited resection, the survival rate was similar in contrast with those treated with lobectomy.[sup][23],[24] Therefore, accurate integration of preoperative lymph node staging in patients with early-stage NSCLC is important in guiding the choices of surgical treatment.
The indication for a completion ALND has changed based on the results of the randomized trial, ACOSOG Z0011.
In the late 1990s, the multicenter American College of Surgeons Oncology Group (ACOSOG) Z0011 trial was initiated to compare the effects of ALND versus SLNB alone on overall survival in patients with SLN metastasis treated with breast-conserving surgery (BCS) and systemic therapy.