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On day 42, a total of 65% (26/40, 95% CI 48.3%-79.4%) had an ACPR, and 35% (14/40) had recrudescence; 4 were withdrawn because they became reinfected.
Efficacy outcome AS/AQ AL N % N % Crude day 14 cure rates 68 69 ACPR 61 89.7 67 97.1 ETF 02 02.9 0 0 LCF 01 01.5 0 0 LPF 04 06.0 02 03.0 Crude day 28 cure rates 61 64 ACPR 54 88.5 62 96.9 ETF 02 03.3 0 0 LCF 01 01.6 0 0 LPF 04 06.6 02 03.1 PCR corrected day 28 56 62 cure rates ACPR 54 96.4 62 100 ETF 02 03.6 0 0 LCF 0 0 0 0 LPF 0 0 0 0 Note: Reinfections were excluded from the analysis after profiling pretreatment and recurrent parasites based on the polymorphic Plasmodium falciparum msp 2 antigen.
Figure 12 shows the ACPR of the traditional DPA and the DPA using CRLH-TL, respectively.
Furthermore, as shown in Table 3 and Figure 12, for 40 MHz 16 QAM signal, the measured results shows a 5.3 dB maximal ACPR improvement at 37 dBm and a 8 dB maximal ACPR improvement at 40 dBm by introducing CRLH-TL.
For the proposed traditional DPA, the DE achieves 31.8% at 9 dB-BOP and 46% at 6 dB-BOP, the ACPR achieves -42.9dBc for 40 MHz 16 QAM signal and -35.3 dBc for 100 MHz LTE-Advanced signal at 9 dB-BOP with DPD.
The W-CDMA ACPRs of the HJFET were measured with a QPSK-modulated signal having a chip rate of 4.096 Mcps at 1.95 GHz; the intermodulation distortions were measured using a two-tone input signal at frequencies of 1.948 and 1.952 GHz.
Figure 10 shows the ACPRs and intermodulation distortions of the HJFET under a higher [I.sub.q] level of 300 mA.
The correlation between W-CDMA ACPRs and HFET intermodulation distortions was discussed.
Although a variety of device technologies are available for power application, it has been demonstrated that HJFET is a leading candidate for W-CDMA handset transmitter applications due to its high PAE and low ACPR characteristics.[5-7] The high PAE is achieved by biasing the HJFET with a very low quiescent drain current [I.sub.q] instead of a higher [I.sub.q] (class A operation); W-CDMA ACPR requirements are satisfied under this operation, attributed to an ACPR dip phenomenon.
Two distinct ACPR characteristics due to different [I.sub.q] operations are addressed and their dependence on optimum load impedances are discussed.
However, for digitally modulated RF carriers, the adjacent-channel protection ratio (ACPR) figure of merit often is preferred since it is based on applying a digitally modulated stimulus whose characteristics are compliant to that particular standard.
In addition, it is generally not possible to draw a simple and accurate relationship between the amplifier's IMD performance for a two-tone sinusoid stimulus to its spectral distortion (measured by ACPR) when driven by a digitally modulated RF carrier.
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