ACR50American College of Rheumatology 50% improvement
References in periodicals archive ?
At week 52, both ACR50 and ACR70 rates were higher in the baricitinib group compared to adalimumab, although only ACR 50 was statistically significant.
ACR50 and ACR70 responses are similar to the ACR20 response, but denote 50 percent and 70 percent improvements, respectively.
The combination of TwHF plus methotrexate was the most effective, with an ACR50 response rate of 76.
Una segunda opcion que tiene el paciente de "AR Primera Linea" es responder parcialmente, sin alcanzar el ACR50 y pasando a un estado 3: que denominamos "Responde <ACR50".
ACR20 or ACR50 does not provide optimal improvement in outcomes.
Positive results from the 12- to 24-week portion of the study, which did not include continuation of the placebo control past week 12, showed that patients who received 2 mg, 4 mg or 8 mg baricitinib once-daily doses maintained or improved ACR20, ACR50 and ACR70 responses.
ORAL Strategy is the first trial to compare a JAK inhibitor as monotherapy or in combination with methotrexate versus adalimumab (Humira) plus MTX in MTX inadequate responders using ACR50 at Month 6 as the primary endpoint.
In terms of ACR disease activity scores, the bar has risen from an ACR20 to an ACR50 or ACR70.
Also, for the two highest dose groups of the study, statistically significant ACR20, ACR50, ACR70, and DAS28 responses were also observed as compared to placebo, and more than one-third of people in these groups achieved clinical remission (DAS28 remission).