(c) The circRNA_021412-miR-1972-LPIN1 signaling controls the pathway of lipid degradation via PPAR[alpha]-induced ACSLs expression.
Members of long chain acyl-CoA synthetase (ACSL) family (ACSL1, ACSL3, ACSL4, and ACSL6) dramatically prevailed in these genes.
In addition, several studies on livestock involving other isoforms of ACSLs have suggested that there is a notable relationship between ACSLs and both carcass and meat quality (Hoashi et al., 2008; Rusc et al., 2011; Fang et al., 2014).
Long-chain acyl-CoA synthetases (ACSLs) and fatty acid transport proteins (FATPs) activate fatty acids (FAs) to acyl-CoAs prior to their downstream metabolism(Catala-Rabasa et al., 2011).
Acyl coenzyme A long-chain 5 synthetase (ACSL5), a member of the ACSL family, plays a key role in fatty acid beta-oxidation and fat synthesis in mammals.
ACSL5, a unique ACSL isoform that is the only isoform to localize on mitochondria, also differs from other family members in its tissue distribution(Mashek, Li, et al., 2006).
Genetic diversity of the ACSL gene in the Chinese Simmental steer population: The genotype frequency and allele frequency calculated for the two polymorphisms of the ACSL5 gene detected in this study are shown in Table 2.
Genotypic frequencies and genetic diversity of ACSL gene in Simmental cattle.