FRETS-VWF73, a first fluorogenic substrate for ADAMTS
* Synovitis Antiinflammatory therapies Table 2 Tissue Specific Therapeutic Targets for DMOAD Development I Cartilage Inhibiting Catabolism * Protease inhibitors of MMP and ADAMTS
* Inducible nitric oxide synthase (iNOS) inhibitor * Cell-signaling pathway inhibitors: MAPK, JNK, p38, ERK1/2, etc.
In the present study, we analyzed the effect of FYC on collagen and proteoglycan, including ADAMTS
, MMPs, IL-1[beta], NO, PGE2, TGF-[beta], HSP70, OPG, and RANKL levels, which are involved in ECM degradation, as well as articular cartilage apoptotic and articular cartilage protective pathways.
Takeda, "ADAM and ADAMTS
family proteins and snake venom metalloproteinases: a structural overview," Toxins, vol.
In addition, inflammatory cytokines contribute to the increased synthesis and release of many proteolytic enzymes that decompose articular cartilage, which include the metallo-proteinases family MMPs and ADAMTS
. Apart from their effect on chondrocytes, synovial cells and other articular, and periarticular tissues, inflammatory cytokines affect the cells of the immune system migrating to the site of inflammation.
Members of ADAMTS
family have been implicated in neurodegenerative and neuroinflammatory diseases [137-139].
Komar et al., "Expression of messenger RNA for ADAMTS
subtypes changes in the periovulatory follicle after the gonadotropin surge and during luteal development and regression in cattle," Biology of Reproduction, vol.
The breakdown of AGC is believed to be initiated by a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS
)-4 and ADAMTS-5.
13 level was reported to be incompatible with TTP.
In humans, nineteen ADAMTS
proteins are encoded in the genome and they can be clustered into eight clades' based on their domain organization and known functions.
A disintegrin and metalloproteinase with thrombospondin motif (ADAMTS
) is a family of ECM proteinases comprising 19 secreted proteolytic enzymes that are structurally and functionally related to matrix metalloproteinases (MMPs) (12).