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ADAMTS-1a disintegrin and metalloprotease with thrombospondin type1 motifs
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ADAMTS-1 is a MMP that has been implicated in the inhibition of angiogenesis induced by luteinizing hormone (LH) in the periovulatory follicles of the mouse and rat and is also thought to be a mediator of proteolytic cleavage of the hyaluronan binding proteoglycans, aggrecan, and versican (16,17).
The secreted active form of ADAMTS-1 has been shown to be localized selectively in COC, and with the effect of LH surge in the periovulatory period, to lead to cleavage of versican (19).
Based on the results of the above-mentioned studies, we hypothesized that altered levels of ADAMTS-1 and versican in the ECM of COC, by causing ovulatory dysfunction, might be causative factors for the clinical manifestations of PCOS.
Serum ADAMTS-1 concentrations were determined by human ADAMTS-1 enzyme-linked immunosorbent assay (ELISA) (Eastbiopharm Co., Ltd., Hangzhou, China) and the results were expressed as ng/mL.
Abbreviations: ADAMTS-1, ADAM metallopeptidase with thrombospondin type 1 motif, 1; MMP-9, matrix metalloproteinase 9.
Expression of ADAMTS-1, -4, -5, and -14 in the Placenta During Gestation
Immunohistochemical analyses of ADAMTS-1, -4, -5, and -14 expression during gestation revealed differential expression patterns in specific cell types in the first-trimester placenta.
In the second-trimester and third-trimester placentas, the patterns and intensities of ADAMTS-1 and ADAMTS-14 expression in the 5 cell types were similar to those in the first-trimester placenta.
Expression of ADAMTS-1, -4, -5, and -14 by Gestational Trophoblastic Diseases
Using the ImpRH panel, we determined that pig ADAMTS-1 was closely linked with microsatellite marker S0215 on SSC13q49 (distance of 76cR, LOD = 4.18, retention frequency = 18%) (Figure 2).
Kawashima et al., "ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan, " FEBS Letters, vol.