Klein speculates that a vaccine that focused on A[beta] in ADDL form, as opposed to plaques, could be more effective, cause less inflammation, and require less vaccine.
Recent work shows that other forms of A[beta] known as A[beta]-derived diffusible ligands, or ADDLs, may, along with senile plaques, play a key role in the pathogenicity of Alzheimer disease.
Founded in 1996, Acumen owns or has licensed the critical patents underlying the ADDL mechanism now widely believed to cause Alzheimer's disease.
Research Team Led by Acumen Co-Founders Finds that Memory-Blocking ADDLs Also Interfere with Brain Insulin Activity
We look forward to continuing to work together to develop and commercialize ADDL diagnostics.
Founded in 1996, Acumen owns or has licensed certain important patents underlying the ADDL mechanism now widely believed to cause Alzheimer's disease.
A serum-based ADDL diagnostic will revolutionize clinical testing of experimental Alzheimer's drugs by enhancing the accuracy of patient selection and by demonstrating whether new treatments can reduce ADDL levels.
3) ADDL receptor binding triggers abnormal signaling, blocking essential memory-forming processes and activating other processes that lead to nerve cell degeneration and death.
ADDL products can seamlessly combine the TV broadcast and IP-delivered content to enable broadcasters to develop compelling new services across entertainment and commerce.
Over the coming period, ADDL will continue to expand its UK presence, building on its already well-established sales channels.
Merck recognizes Acumen's leadership in the field of ADDL research, and we are pleased to enter into this collaboration to discover and develop breakthrough medicines for what is a significant unmet medical need," said Mervyn Turner, Ph.
It marks a shift from research on ADDLs and how they operate in Alzheimer's disease, to the development of effective therapeutic and preventative drugs.