Detection of ADH2, ADH3, and ALDH2 was performed using previously described methods [Nakamura et al.
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.
Charlotte Bronte Variation In Relative Risk of MI by ADH3
Allele Nondrinker At least 1 drink/d gamma 1 allele 1 0.
The only ADH genes exhibiting polymorphisms are ADH2 and ADH3
, and the kinetic properties show only a small difference among ADH3
A comparison of the genotypes of ALDH2, ADH2, ADH3
, and cytochrome P-450E1 between alcoholics and nonalcohlics.
These primers were designed as mismatched 3'-end nucleotides of the ADH1 or ADH3
alleles for amplifying only the ADH2 allele.
genotype, alcohol intake and breast cancer risk.
Frenzer and colleagues (2002) conducted a case-control study comparing the genes for ADH2, ADH3
, ALDH2, and CYP2E1 in 57 Caucasian patients with alcoholic cirrhosis, 71 patients with alcoholic CP, 57 alcoholics without any apparent organ damage, and 200 healthy blood donors.
Research originally suggested that only the subtype ADH3
was expressed in the brain and that ethanol was not a good candidate for that enzyme to act on (i.
Of these, ADH3
has two common genetic variants, or alleles, that break down ethanol at different speeds (i.
Newer studies have suggested that certain ADH2 and ADH3
alleles also protect carriers to some extent from developing alcoholism.
alcohol dehydrogenase) at two genes called ADH2 and ADH3
did not predict differences in alcohol reactivity, even though the ADH2*2 gene variant (i.