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ADH4alcohol dehydrogenase 4 gene
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To see how ADH4 evolved, Benner's team read the stretches of DNA that make ADH4 in 27 modern primate species, including lemurs, monkeys, apes and humans.
ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: Results from HWD tests and case-control association studies.
Among these, variations in and near ADH4 are among the most widely replicated associations with alcohol dependence, in several populations.
Some of the COGA victories include associations that have been subsequently substantiated by other investigations, such as GABA receptor alpha (GABRA2), cholinergic muscarinic 2 receptor (CHRM2), and ADH4 (Edenberg and Froud 2006).
ADH4 encodes [pi]-ADH, which contributes significantly to ethanol oxidation at higher concentrations (Table 2).
isozyme] belonging to the class I ADH) is the most efficient for this substrate, ADH4 is about 10 times less efficient, and ADH3 is nearly inactive toward alcohol.
3]-ADH (encoded by ADH4 and ADH1B genes, respectively) and CYP2E1 (Bosron et al.