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ADH5alcohol dehydrogenase 5 gene
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ADH5 is a cocktail of immunohistochemical markers that includes CK8/18-pink, CK5/14-brown, and p63-brown (hematoxylin-eosin, original magnifications x40 [A], X200 [B], x100 [E], and x400 [G]; CK5, original magnifications X200 [C] and x100 [F]; p63, original magnification X200 [D]; ADH5, original magnification x400 [H]).
--Susanne Hiller-Sturmhofel Table 1 Alcohol Dehydrogenase (ADH) Genes and Proteins Official Gene Nonstandard Name* Old Name ([dagger]) Name ([double dagger]) ADH1A ADH1 ADH1A ADH1B ADH2 ADH1B ADH1C ADH3 ADH1C ADH4 ADH4 ADH2 ADH5 ADH5 ADH3 ADH6 ADH6 ADH5 ADH7 ADH7 ADH4 Official Gene Name* Sequence ([section]) Protein Class ([paragraph]) ADH1A NM_000667 [alpha] I ADH1B NM_000668 [beta] I ADH1C NM_000669 [gamma] I ADH4 NM_000670 [pi] II ADH5 NM_000671 [chi] III ADH6 NM_000672 ADH6 V ADH7 NM_000673 [sigma] IV *Gene symbol approved by the Human Genome Organization (HUGO) Gene Nomenclature Committee (, as used by the National Center for Biotechnology Information (NCBI).
In addition to the widely replicated associations between the rs1229984 and rs671 with alcoholism risk, certain variants in other genes encoding alcohol-metabolizing enzymes, such as ADH1C, ADH4, and ADH5, also have been linked to alcohol dependence in other populations.
Table 1 Human Alcohol Dehydrogenase (ADH) Isozymes Gene Nomenclature [K.sub.m] [V.sub.max] Class New Former Protein mM [min.sup.-1] I ADH1A ADH1 [alpha] 4.0 30 ADH1B*1 ADH2*1 [[beta].sub.1] 0.05 4 ADH1B*2 ADH2*2 [[beta].sub.2] 0.9 350 ADH1B*3 ADH2*3 [[beta].sub.3] 40.0 300 ADH1C*1 ADH3*1 [[gamma].sub.1] 1.0 90 ADH1C*2 ADH3*2 [[gamma].sub.2] 0.6 40 II ADH4 ADH4 [pi] 30.0 20 III ADH5 ADH5 [chi] >1,000 100 IV ADH7 ADH7 [sigma]([mu]) 30.0 1,800 V ADH6 ADH6 ?