The aim of this study is to determine the early evolution, associations, and correlations of high-sensitivity troponin T (hsTnT) in
ADHF.
Briefly, 599 dyspneic patients treated in an urban ED were enrolled in a study for the purpose of validating the value of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) for diagnosis of
ADHF in this setting.
Cardioxyl's lead program is focused on the development of proprietary nitroxyl donors for the treatment of acute decompensated heart failure (
ADHF).
The
ADHF's Digestive Health Initiative (DHI) currently is involved in a number of educational efforts, including the Ulcer, Colorectal Cancer and Viral Hepatitis Education Campaigns.
Additionally, the company expects to launch a 500-patient multi-centre Phase 2b clinical trial for TRV027 in
ADHF patients by year end.
2 August 2010 - US pharmaceutical company Cardioxyl Pharmaceuticals Inc said today it has achieved positive safety and tolerability results in the first clinical study of its lead drug candidate, CXL-1020, for the treatment of patients with acute decompensated heart failure (
ADHF).
The study, NIL-CDNP-CT005, was designed to provide additional information on the safety and tolerability of CD-NP when infused for up to 72 hours in patients with
ADHF and mild to moderate renal insufficiency.
Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (
ADHF) with worsening renal function.
Acute decompensated heart failure (
ADHF) is associated with abnormal hemodynamics especially left ventricular filling pressure and cardiac output.
In the United States,
ADHF accounts for approximately half of all heart failure-related causes of hospitalisation.
In the BACH Study, amongst 1641 patients presenting to the emergency department with dyspnea, MR-proANP >120 pmol/L proved noninferior to BNP >100 pg/mL for the diagnosis of acute decompensated HF (
ADHF); MR-proANP added to the utility of BNP in patients with intermediate BNP values and with obesity but not in renal insufficiency, the elderly, or patients with edema (7).
Nevertheless, a significant proportion of the patients admitted to the hospital for acute decompensated heart failure (
ADHF) is discharged with unresolved congestion.