The aim of this study is to determine the early evolution, associations, and correlations of high-sensitivity troponin T (hsTnT) in ADHF
Briefly, 599 dyspneic patients treated in an urban ED were enrolled in a study for the purpose of validating the value of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) for diagnosis of ADHF
in this setting.
Cardioxyl's lead program is focused on the development of proprietary nitroxyl donors for the treatment of acute decompensated heart failure (ADHF
's Digestive Health Initiative (DHI) currently is involved in a number of educational efforts, including the Ulcer, Colorectal Cancer and Viral Hepatitis Education Campaigns.
Additionally, the company expects to launch a 500-patient multi-centre Phase 2b clinical trial for TRV027 in ADHF
patients by year end.
2 August 2010 - US pharmaceutical company Cardioxyl Pharmaceuticals Inc said today it has achieved positive safety and tolerability results in the first clinical study of its lead drug candidate, CXL-1020, for the treatment of patients with acute decompensated heart failure (ADHF
The study, NIL-CDNP-CT005, was designed to provide additional information on the safety and tolerability of CD-NP when infused for up to 72 hours in patients with ADHF
and mild to moderate renal insufficiency.
Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF
) with worsening renal function.
Acute decompensated heart failure (ADHF
) is associated with abnormal hemodynamics especially left ventricular filling pressure and cardiac output.
In the United States, ADHF
accounts for approximately half of all heart failure-related causes of hospitalisation.
In the BACH Study, amongst 1641 patients presenting to the emergency department with dyspnea, MR-proANP >120 pmol/L proved noninferior to BNP >100 pg/mL for the diagnosis of acute decompensated HF (ADHF
); MR-proANP added to the utility of BNP in patients with intermediate BNP values and with obesity but not in renal insufficiency, the elderly, or patients with edema (7).
Nevertheless, a significant proportion of the patients admitted to the hospital for acute decompensated heart failure (ADHF
) is discharged with unresolved congestion.