On this background, we hypothesized that ADMA
and SDMA levels might be predictive of the cardiovascular risk, all-cause mortality, and renal function of patients with anti-neutrophil-cytoplasmic antibodies (ANCA)-associated small vessel vasculitis (AASV) subjected to well-defined treatment regimens in four European Vasculitis Study Group (EUVAS) trials.
"This patent is the first of its kind for use of a polyclonal immunoglobulin preparation for treatment of respiratory infection and, in conjunction with three previously issued patents to ADMA
, further protects our proprietary immune globulin technology for the prevention and treatment of infection," commented Adam Grossman, president and CEO of ADMA
Regarding the analysis of L-arginine, ADMA
, and SDMA in human plasma, sample preparation by SPE using cation-exchange columns is the currently preferred approach [10-13].
The first methylation leads to the formation of monomethylarginine (MMA), while the second one can produce either symmetric dimethylarginine (SDMA) or ADMA
, according to the PRMT isoform involved in the methylation reaction .
Under the deal, Adma
will secure ownership and control of US based immune globulin manufacturing facility and an FDA licensed products portfolio with immediate and on-going commercial sales.
Asymmetric dimethylarginine (ADMA
), an endogenous NO synthase inhibitor, was reported to inhibit the mobilization, differentiation, and function of EPCs .
The conditions which increase the chances of developing CAD among T2DM patients are called risk factors, according to the American Diabetic Association.10,11 They include positive family history for CAD, age (>45 years for men, >55 years for post-menopausal women), gender (male>female), BP >140 systolic >90 diastolic, body mass index (BMI) >25Kg/m2, hypercholesterolaemia (Low High-density lipoprotein cholesterol [HDL-C] > low-density lipoprotein cholesterol [LDL-C]), triglycerides (TGs) >150mg/dl, fasting blood glucose (FBG) >125mg/dl and raised ADMA
is a strong predictor of impairment in endothelial function, there is lack of evidence in the literature as to whether increased levels of ADMA
correlate with ED in patients with CKD.
Conclusion: Our study reveals increased serum ADMA
levels in the patients suffering from type 2 diabetes mellitus without CAD when compared with the control group.
Umm Shaif, the first offshore field found in March 1958 by ADMA
, is one of the biggest in the Middle East - 20x15 km.
's initial plan was to pig the riser to make the riser free from hydrocarbon fumes.