ADMET


Also found in: Medical.
AcronymDefinition
ADMETAcyclic Diene Metathesis
ADMETAbsorption, Distribution, Metabolism, Excretion and Toxicity (drug properties; also seen as ADMETOX)
References in periodicals archive ?
Unlike single target approaches, Ligand Design focuses on a drug's polypharmacology and explores synthetically accessible chemical space to de novo design small molecules against a collection of targets and anti-targets, while simultaneously selecting for physicochemical and ADMET properties.
Ligand Design concentrates on a drug's polypharmacology and explores synthetically accessible chemical space to de novo design small molecules against a collection of targets and anti-targets, while simultaneously choosing physicochemical and ADMET properties.
The compounds with highest pharmacophore fit score were further screened through their different physical properties such as Ro5, toxicity and ADMET parameters.
In addition to this latest award, AMRI has three other prime contracts with the NIH and serves as a dedicated center for the National Cancer Institute's (NCI) Chemical Biology Consortium (CBC), providing medicinal chemistry, compound profiling, in vitro ADMET, protein biochemistry, cancer cell biology and preclinical development services, as needed.
David Miller, principal scientist and project leader for ADMET Predictor, said This update builds upon the significant refactoring of the version 8.0 release this past summer, with a particular focus on enhancements to better serve research groups working with large data sets.
Thanks are due to Pharmago Company Limited, CN, for the assistance with the ADMET in silico experiments.
Lead Finder satisfies the needs of computational chemists and medicinal chemists involved in the discovery process, pharmacologists and toxicologists involved in the modeling and evaluation of ADMET properties in silico, and biochemists and enzymologists working on enzyme specificity and rational enzyme design.
(NASDAQ: SLP) said that The Dow Chemical Company (NYSE: DOW) has licensed both its best-in-class GastroPlus and ADMET Predictor software programs.
Serial dilution can be used in assay development to determine appropriate concentration ranges; in secondary screening to evaluate pharmacological response; and in early ADMET studies to determine toxicological effects.