Additionally, the overall ADNI
study collaborates too, partnering with other related Alzheimer's Disease studies to form a larger study cohort--which equates to more data and enhanced scientific results.
Davatzikos, "Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI
," Neuroimage, vol.
However, a 2015 study using a similar ADNI
cohort localized some of them to specific amyloid-burdened brain regions (J Alzheimers Dis.
In the ADNI
studies, the measures were done using a multiplex approach with the INNO-BIA AlzBio3 test adapted on the Luminex platform.
is the result of efforts of many co-investigators from a broad range of academic institutions and private corporations, and subjects have been recruited from over 50 sites across the U.
model of AD progression described suggests when biomarkers and imaging techniques are likely to be most useful in diagnosis, tracking disease progression, and assessing effectiveness of treatments.
The studies coming out of the ADNI
initiative are among the most clinically important research initiatives we have seen," says neuropsychiatrist Kaloyan Tanev, MD, of the Neuropsychiatry Clinic at Massachusetts General Hospital.
In the ADNI
, a phantom scan is acquired along with each patient study.
National Institute on Aging's Alzheimer's Disease Neuroimaging Initiative, or ADNI
For more information on ADNI
, call the NIA's Alzheimer's Disease Education and Referral (ADEAR) Center at 1-800-438-4380, or visit www.
researchers will employ serial magnetic resonance imaging (MRI); positron emission tomography (PET) scans; measurement of various biological compounds in blood, cerebrospinal fluid, and urine; and clinical and neuropsychological assessments to track MCI and early AD progression.
and the University of Pennsylvania, Philadelphia, will carry out extensive profiling of plasma samples from 900 ADNI
participants and from participants in the Duke University MURDOCK Memory and Cognitive Health Study in search for lipid metabolites that are associated with cardiovascular disease and cognitive change.