AEC IIAlveolar Epithelium Cells of Type II
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After being differentiated into Clara cells and AEC I and AEC II cells, Oct3/4 was gradually silenced, together with the observation that Nanog was copositively expressed in Oct3/4(+) cells, which may illustrate that Oct3/4(+) cells were undifferentiated or with multidifferentiation ability.
In addition, Clara cells have secretory granules, secreting protease and many enzymes, and AEC II cells can release surface active substances.
Clara cells and AEC II cells do not match the definition of stem cells, due to not only their large number but also their specific secretory function.