AECOPDAcute Exacerbations of Chronic Obstructive Pulmonary Disease
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In clinical studies, B*R*A*H*M*S PCT assay has been shown to reduce the antibiotic prescription rate and duration in patients with LRTI, defined as community-acquired pneumonia (CAP), acute bronchitis, and acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Infections are the most common cause of AECOPD, three classes of pathogens have been implicated as a cause of COPD exacerbation: respiratory viruses, atypical bacteria, aerobic gram positive and gram-negative bacteria.
Chronic obstructive pulmonary disease (COPD) is predicted to be the third leading cause of mortality worldwide by 2020.1,2 COPD exacerbation is defined as an acute event characterised by worsening of patient's respiratory symptoms that is beyond normal day-to-day variations and leads to a change in medication.2 Acute exacerbations of COPD (AECOPD) are not only a cause of high mortality in these patients 3 but are also responsible for significant number of unscheduled hospital visits 4 and thus increased healthcare expenditure.
The morbidity and mortality associated with chronic obstructive pulmonary disease (COPD) exerts a considerable economic burden,[1] a large proportion of which has been contributed by the occurrence of acute exacerbation of COPD (AECOPD),[2] especially for the hospitalization of AECOPD.[3] Therefore, it is essential to early identify COPD patients who are at-risk of acute exacerbation and determine whether hospitalization is necessary.
Patients who were admitted to ICU, diagnosed with AECOPD due to hypercapnic respiratory failure, and required mechanical ventilatory were included in the study between December 2015 and December 2016.
4, 2018 (HealthDay News) -- The frequency of acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) in a single year predicts the long-term rate of AECOPDs, according to a study recently published in the American Journal of Respiratory and Critical Care Medicine.
Acute Exacerbations of COPD or 'AECOPD's are caused by complex interactions between the patient's immune system, respiratory viruses, and airway bacteria, which aggravate the inflammatory status of the airway.
For example, AECOPD and active TB infection upregulated, while systemic CS or IS therapy suppressed the expression of IL-1B, and thus should be on guard in the clinical use of this cytokine as a monitor of the activity of CPA.
Conclusion: Levels of CRP in combination with PCT is a reliable index for determining the existence of bacterial infection, which is of great clinical guidance significance to the treatment and prognosis assessment of AECOPD patients.
The host inflammatory response is an important component of AECOPD. The profile of inflammatory markers may be used to classify airway inflammation in AECOPD with heterogeneous inflammation [8].
Hui, "An adjunct intervention for management of acute exacerbation of chronic obstructive pulmonary disease (AECOPD)," Journal of Alternative and Complementary Medicine, vol.