AFLTSAssociation Free Lutheran Theological Seminary (est. 1964; Plymouth, MN)
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(10) The formation of biofilms is important for the failure of AfLT; since it is one of the major virulence factors resulting in significant resistance to antifungal therapy by limiting the penetration of substances through the matrix and protecting cells from host immune responses.
(15) According to our experience; higher concentrations of caspofungin might be required for AfLT for Candida parapsilosis.
Since there is inadequate clinical data for forming the base for specific recommendations for AfLT in the management of catheter-related infections and lack of standardization of the dosage, duration and intraluminal time spent; randomized clinical trials are essential.