In Zambia, Population Council researchers are implementing and evaluating the Adolescent Girls Empowerment Program (AGEP
) using a randomized control trial, in order to provide strong evidence of the intervention's impact.
The histopathology of AGEP
is typically spongiform subcorneal and/or superficial intraepidermal pustules accompanied with edematous papillary dermis and large amounts of perivascular infiltrates (Figure 3) [37, 38].
Skin lesions appeared 3 weeks earlier, the first time in his life, after a few weeks of taking atenolol, which could suggest AGEP
, and so the drug was discontinued.
The acute rash with minute pustules and associated leukocytosis with neutrophilia and eosinophilia led to an early diagnosis of AGEP
, which may have been triggered by azithromycin--the patient's only recent medication.
Acute generalized exanthematous pustulosis (AGEP
) is an uncommon skin eruption characterized by superficial nonfollicular aseptic pustules.
(4) TNF-[alpha], IFN-[gamma], TARC, IL-15, and Other Cytokines/ Chemokines in SJS/TEN, DRESS/DIHS, and AGEP
. TNF-[alpha] is a major proinflammatory cytokine and is produced by macrophages, T lymphocytes, NK cells, neutrophils, mast cells, and eosinophils.
In addition, the flavonoids found in MH could counteract effectively the oxidative stress induced by AGEP
in diabetics .
The features were suggestive of AGEP
. The patient was advised to stop the drugs and prescribed with oral methyl prednisolone (28 mg) in tapering dose over 2 weeks.