AGTR2Angiotensin II Receptor, Type 2
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The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI.
The report provides comprehensive information on the Type-2 Angiotensin II Receptor (Angiotensin II Type-2 Receptor or AT2 or AGTR2), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
* The report provides a snapshot of the global therapeutic landscape for Type-2 Angiotensin II Receptor (Angiotensin II Type-2 Receptor or AT2 or AGTR2)
Guo et al., "Associations between Genetic Variants in the ACE, AGT, AGTR1 and AGTR2 Genes and Renal Function in the Multi-Ethnic Study of Atherosclerosis," American Journal of Nephrology, vol.
These include genes of renin (R14+17G), angiotensinogen (AGT), angiotensin receptors (AGTR1, AGTR2), ACE and endothelial NOS (eNOS), endothelin-1 (BsiY1) and kallikrein (S1386A, A1789G), aldosterone (SYP11B2), ([beta]1-adrenoceptor (ADR[beta]1), catecholamines metabolism enzymes genes, glucagon, II [beta]-hydroxylase, genes associated with insulin resistance (PC-1 k121q, PPAR-g2), etc.
For instance, CC2D1A, TRAPPC9 (on autosome) and AGTR2, GDI1 ( on X chromosome) are involved in signal transduction and in some case they share the common pathway (Table -2).
[4] Human genes: APOE, apolipoprotein E; UCP2, uncoupling protein 2 (mitochondrial, proton carrier); LPL, lipoprotein lipase; APOA4, apolipoprotein A-IV; IL6, interleukin 6 (interferon [[beta].sub.2]); PECAMI platelet/ endothelial cell adhesion molecule (CD31 antigen); AGTRI, angiotensin II receptor, type 1; AGTR2, angiotensin II receptor, type 2; BDKRBI, bradykinin receptor B1; BDKRB2, bradykinin receptor B2; PPARA, peroxisome proliferator-activated receptor-[alpha]; F7, coagulation factor VII (serum prothrombin conversion accelerator); CETP, cholesteryl ester transfer protein.