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AIB1Amplified in Breast Cancer 1
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In studies involving a range of breast cancer cell lines, through miR-17-5p inhibiting translation, AIB1 expression was reportedly downregulated.
Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu.
In contrast, AIB1 has been associated with poor outcome on tamoxifen in HER2-amplified breast cancer because HER2 activates AIB1 and enhances the agonist effects of tamoxifen [33,34].