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AIB1Amplified in Breast Cancer 1
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Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of aib1 mRNA.
Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu.
The co-activator NCOA3, also known as amplified in breast cancer-1 (AIB1) is overexpressed in 50% of breast cancers and amplified in 5% [32].