AIMAHACTH (Adrenocorticotropic Hormone)-Independent Macronodular Adrenocortical Hyperplasia (aka ACTH-Independent Macronodular Adrenal Hyperplasia)
AIMAHACTH (Adrenocorticotropic Hormone)-Independent Macronodular Adrenal Hyperplasia (aka ACTH-Independent Macronodular Adrenocortical Hyperplasia)
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Standard therapy for clinical AIMAH is bilateral adrenalectomy, which can remove the source of serum cortisol radically, with 5-year survival rates being 66% to 70%.
Once AIMAH develops into high-risk AIMAH, the disease would develop quickly, accompanied by hypokalemia, hyperglycemia, severe hypertension and exhaustion of multiple organs.
There are various medications, such as ketoconazole, mitotane and metyrapone, to decrease serum cortisol for high-risk AIMAH.
Pharmaceutical intervention of the aberrantly expressed adrenal receptors in AIMAH has been attempted in only a few cases with conflicting results.