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We compared patients with AIP1 to those with AIP2 with regard to clinical and serological differences and surveyed the following characteristics: origin, gender, age, body mass index (BMI), concurrent autoimmune cholangitis (AIC), overlap to ulcerative colitis (UC), development of malignancies, response to steroid treatment, rate of relapse, immunosuppressive regimen, and profiles of serological and genetic markers.
The majority of patients suffered from AIP1 (55.6% versus 44.4% with AIP2).
AIP1 patients predominantly revealed a cholestatic course when firstly diagnosed (median bilirubin in AIP1 2.3 mg/dl versus 0.5 mg/dl in AIP2, p < 0.001; median alkaline phosphatase (AP) in AIP1 264.0 U/l versus 75.0 U/l in AIP2, p <0.05; and finally, median y-glutamyltransferase (y-GT) in AIP1 337.0 U/l versus 37.5 U/l in AIP2, p <0.05; Figures 3(a), 3(b), and 3(c)).
Antibody profiles were available in 19/20 AIP1 patients and in all AIP2 patients.
Response to steroid treatment was excellent in both groups as shown in Table 2 (AIP1 19/20 = 95.0% versus AIP2 15/16 = 93.8%).
We found 3 patients in the AIP1 group who developed CCC.
Jeon et al., "A carbohydrate fraction, AIP1 from Artemisia iwayomogi suppresses pulmonary eosinophilia and Th2-type cytokine production in an ovalbumin-induced allergic asthma.
Jeon et al., "AIP1, a carbohydrate fraction from Artemisia iwayomogi, modulates the functional differentiation of bone marrow-derived dendritic cells," International Immunopharmacology, vol.
AIP1 was reported to play a prominent role in paraptosis.
Caption: Figure 5: After exposure to 2 Gy of [sup.125]I seeds radiation the expression of AIP1 decreased.
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