We recommend implementation of the latest edition (7th edition) of AJCC
classification for eyelid carcinomas into the practice of all surgeons and clinicians who manage eyelid carcinomas throughout the world.
A new feature of the 7th edition of the AJCC
Cancer Staging Manual (2) will be the ability to collect data on biomarkers and additional data points in an attempt to extend the classification system beyond solely an anatomic-based one.
As well written as the 5th edition of the AJCC
Cancer Staging Manual is, this commentary is virtually essential for its optimal use, as was the 1st edition of this supplement, which was published in 1993.
A recent retrospective study concluded that the staging as per AJCC
8th edition would vary in 3.9% patients if depth and thickness were interchangeably used.
Within each AJCC
stage, DecisionDx-Melanoma further stratified risk of melanoma-specific mortality.
Bladder neck invasion was designated as pT4 disease in the 2002 AJCC
TNM staging system, whereas, microscopic bladder neck invasion was categorized as pT3a cancer in the 2009 TNM (21).
8 is "significantly better" than AJCC
7 in its incorporation of meaningful risk factors into the SCC staging system, "it still underperforms in comparison" with the BWH staging system using the 2,000-patient cohort, he said.
Thus, per AJCC
criteria, the tumor was T4aN0M0 and technically stage IIB.
Determination of T for AJCC
TNM classification of breast carcinoma: staging implications of utilizing imaging studies & gross examinations vis a vis microscopic evaluations on needle core biopsies & excisions.
Elmore, M.D., M.P.H., from the University of California, Los Angeles, and colleagues compared AJCC
8 with the AJCC
Cancer Staging Manual, 7th edition (AJCC
7) in a diagnostic study.
The eighth edition is built upon an AJCC
database of more than 46,000 patients with stage I-III melanoma diagnosed since 1998 at 10 academic medical centers.
The number of metastatic LNs is a promising novel predictor of survival with demonstrated superiority to the 8th edition AJCC
N classification in a variety of squamous cell head and neck cancers [6-9].