The cream of Boswellia serrata Roxb extract standardized for 5% of 95% 3-O-Acetyl-ll-Keto Beta Boswellic Acid (AKBBA
) was studied in an open label, multi-centered phase III clinical trial, evaluating 200 psoriatic patients with application of AKBBA
cream three times daily for a period of 12 weeks.
The analysis of ethanolic extract of Boswellia serrata showed the presence of KBBA (keto beta bowswellic acid), AKBBA (acetyle keto beta bowswellic acid) at 254nm and BBA (beta bowswellic acid), ABBA (acetyle beta bowswellic acid) at 210 nm in extract (Fig.
HPTLC analysis showed 3.4% 11-keto-[beta]-boswellic acid (KBA), 2.5% acetyl-11-keto-[beta]-boswellic acid (AKBA) and 25.8% 3-acetyl-11-keto-[beta]-boswellic acids (AKBBA) (unpublished data) in Boswellia serrata extracts.