AKRSAnna Kaara Raaja Sindhooram (hypolipidemic agent)
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Carbonyl compounds Carbonyl clearance Acrolein (C[H.sub.2]=CHCHO) Glyoxal (OHCCHO) Methylglyoxal (C[H.sub.3]COCHO) (1) Glutathione-S-transferases (GST) catalyze carbonyl- glutathione conjugation Crotonaldehyde (C[H.sub.3]CH=CHCHO) (2) Aldehyde reductase and aldo-keto reductases (AKRs) catalyze reduction to alcoholic forms Malondialdehyde (OCHC[H.sub.2]CHO) (3) Aldehyde dehydrogenases catalyze oxidation to carbonic acids 4-Hydroxynonenal (OCHCH=CHCH(-OH) [(C[H.sub.2]).sub.4]C[H.sub.3]) Table 3: Carcinogenic role of carbonyl compounds.
After oxidation, compounds are reduced or conjugated by a large suite of gene families including glutathione-S-transferases (GSTs), sulfotransferases (SULTs), and aldo-keto reductases (AKRs).
Under Mayakovsky's statue a skinny and a fat thug fought with knives over a wad in broad daylight, until six camouflaged soldiers toting AKRs showed; the thugs split the cash fiftyfifty and ran.