AKTLAdvancing Knowledge Transforming Lives (Michigan State University networks)
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Caption: Figure 5: Effects of AS and APN on the expression of Aktl and Akt2 in the liver.
AKTL = [N.summation over (i = 1)][[absolute value of ST].summation over (t = 1)]F[R.sub.it]/L (4)
In order to make the value of equitability of key-term linkages be a positive value, we divide AKTL by the standard deviation value.
In the table, CKT represents coverage of key terms; AKT represents activation of key terms; EKT represents equitability of key terms; CKTL represents coverage of key-term linkages; AKTL represents activation of keyterm linkages; and EKTL represents equitability of key-term linkages.
The analysis indicated that CKT (r = 0.54, p = .002), AKT (r = 0.63, p = .000), CKTL (r = 0.48, p = .006), AKTL (r = 0.64, p = .000) and EKTL(r = 0.36, p = .046) were positively correlated with QOD.
To investigate EGFR, Aktl, and PTEN, real-time quantitative PCR (qPCR) was used.
Western blots showed expression of Aktl, p-Aktl (pT308, pS473), PTEN, and EGFR in the tumor tissue homogenates (Figure 3(a)).
Immunohistochemistry was used to identify the expression level and spatial distribution of EGFR, PTEN, and Aktl expression (Figure 3(c)).
Expression of PTEN, EGFR, and Aktl mRNA in the PI3K/Akt Pathway.
For example, cells lacking Aktl (but not Akt2) did not stimulate LPA-dependent migration.
Lysophosphatidic acid induces cell migration through the selective activation of Aktl. Exp.