ALDHAldehyde Dehydrogenase
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Oxidation of toxic aldehydes to carboxylic acids is of functions of ALDHs those belong to a family of NAD(P) + -dependent enzymes.
In adult corneal stroma, CSCs are mitotically quiescent, with a flat, dendritic morphology, and are positive for CD34 and ALDH expression.[2] During corneal wound healing, CSCs are activated and transformed into fibroblasts, myofibroblasts, or both, losing their dendritic morphology [1] and resulting in a reduction in ALDH levels [15] and corneal transparency.
When the researchers investigated mice without ALDH, they found that alcohol caused four times as much damage to DNA when compared with mice that could produce ALDH.
In the study, when mice lacking the critical ALDH enzyme - ALDH2 - were given alcohol, it resulted in four times as much DNA damage in their cells compared to mice with the fully functioning ALDH2 enzyme.
ACLY, ATP citrate lyase; MIG12, midline-1- interacting G12-like protein; FASN, fatty acid synthase; NR1D1, Rev-ErbA[alpha]; KLF4, Kruppel-Like Factor 4; ALDH, aldehyde dehydrogenase; Nox1, NADPH oxidase 1; ROS, reactive oxygen species; VEGF, vascular endothelial growth factor.
In relation to cancer cells, the drug limits the activity of ALDH, causing a reduction in decreased tumour cell growth, as well as increased destruction of lung cancer stem cells.
[2] Nonstandard abbreviations: CTCs, circulating tumor cells; ALDH, aldehyde dehydrogenase; EpCAM, epithelial cell adhesion molecule; MET, mesenchymal-epithelial transition; NSCLC, non-small cell lung cancer; TERT, telomerase reverse transcriptase.
(1999) studied the nature and character of Badh2 allele and stated that it belongs to the aldehyde dehydrogenases (ALDH) superfamily which is also involved in the responses to environmental stresses and tolerance character of the plant (Sophos and Vasiliou, 2003).
Bu metodlardan biri retinoid metabolizmasi ve HKH'lerin siklofosfamid gibi alkilleyici ajanlara direncinde rol oynayan sitozolik aldehid dehidrogenaz (ALDH)'dir.
Acetaldehyde dehydrogenase (ALDH) then converts acetaldehyde into acetate.
[67] were able to investigate ADH (alcohol dehydrogenase) and ALDH