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ALDH2Aldehyde Dehydrogenase 2 Family
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Abbreviations: ACE: angiotensin-converting enzyme; ACh: acetylcholine; ALDH2: aldehyde dehydrogenase 2; ARB: angiotensin II receptor blocker; CAS: coronary artery spasm; CCB: calcium-channel blocker; ECG: electrocardiogram; e-NOS: endothelial nitric oxide synthase; hsCRP: high-sensitivity C-reactive protein; ISDN: isosorbide dinitrate; LDL: low-density lipoprotein; L-NMMA: L-monomethyl-arginine; MI: myocardial infarction; MLC: myosin light chain; MLCK: myosin light chain kinase; MLCP: myosin light chain phosphatase; NO: nitric oxide; NOS: nitric oxide synthase; PCI: percutaneous coronary intervention; ROCK: Rho-associated kinase; ROS: reactive oxygen species.
Three general studies have found that the two Asian alleles of the ALDH2 gene result in very different physical responses to the ingestion of alcohol.
Furthermore, a large body of research has highlighted the role of ALDH2 in cardioprotection by combating oxidative stress through a reduction of the cellular aldehydic load (reviewed in (38)).
The study said that over 540 million people in Asia carry a mutation in the ALDH2 gene, which means they can't process acetaldehyde which causes the widely documented red flush reaction in Asians.
Wall, "Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans," Journal of Studies on Alcohol, vol.
Zhou et al., "A Novel Polymorphism rs1329149 of CYP2E1 and a Known Polymorphism rs671 of ALDH2 of Alcohol Metabolizing Enzymes Are Associated with Colorectal Cancer in a Southwestern Chinese Population," Cancer Epidemiology Biomarkers and Prevention, vol.
Our data showed that HDGF induced PKC[epsilon] phosphorylation (Figure 4(c)).Phosphorylated PKC[epsilon] has been shown to translocate into mitochondria and interacts with ALDH2 contributing to 4-HNE detoxification during reperfusion injury [24].
miR-28 [105] and miR-34a [106] block the expression of mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2), which activates activating AMPK and Akt-mTOR signaling and protecting cardiomyocytes against I/R injury.
Background: Aldehyde dehydrogenase 2 (ALDH2) is involved in the pathophysiological processes of cardiovascular diseases.
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis.
Ethanol-induced oxidative DNA damage and CYP2E1 expression in liver tissue of Aldh2 knockout mice.
Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history.