Lung function measurements of infants with ALRTI were conducted 1 day after diagnosis during the acute phase and 3 months after the first lung function test.
During the study period, 1859 infants with ALRTI were seen in the outpatient Department of Respiration of the Children's Hospital of Fudan University.
All the infants with ALRTI completed 1-year follow-up.
All the infants with ALRTI had an acute course <5 days.
Compared with the control group, infants with ALRTI (both wheeze and no wheeze groups) had more family members and a higher incidence of underlying cardiopulmonary condition.
Infants with ALRTI had lower TPTEF/TE, VPTEF/VE, and TEF25 than infants in the control group.
This was confirmed in this study, where ALRTI was the leading cause of both admissions and deaths, followed by AGE.
57 SD Interventions (%) 0 8 7 18 1 17 48 52 2 50 32 22 3 25 13 8 ALRTI (%) 33 32 35 AGE (%) 25 23 37 Fig.
The incidence of RSV-associated severe ALRTI in children from developing and developed countries (5.
25] Although HIV-infected children with RSV-associated ALRTI are at increased risk of hospitalisation and death, this could be due to greater susceptibility to Pneumocystis jirovecii pneumonia and other co-infections.
The diagnosis of ALRTI was reached based on clinical criteria (fever, cough, tachypnea, rales or wheezes on auscultation), supplemented by radiological (hyperinflation, opacities) and gasometric (hypoxemia, hypercapnia, respiratory acidosis) criteria.
Results given are based on the analysis of 21 infants aged between zero and 12 months hospitalized in the PICU for ALRTI.