AM PEFA Small Decline in Morning Peak Expiratory Flow
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Patients recorded the following data on daily diary cards: peak expiratory flow rate, measured before taking asthma medications immediately upon rising in the morning (AM PEF) and immediately before bedtime (PM PEF); self-assessed asthma symptoms; use of asthma medications, including supplemental albuterol inhalation; and nocturnal awakenings due to asthma.
Study medication was self-administered following the AM PEF rate measurement and at bedtime following the PM PEF rate measurement.
A significant treatment benefit in the AM PEF rate was achieved with salmeterol therapy and was maintained throughout the study period to produce a significant overall improvement compared with placebo (P [is less than] .001), regardless of whether the patients were weaned or not weaned (Figure 1).