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AMACRAlpha-Methylacyl-CoA Racemase
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Results: Out of the total 80 cases, 68 (85%) were positive for AMACR while 12 (15%) were negative.
The tumour cells were positive for CK7 and CK20 (figure 2A and B) and negative for CDX2, PSA and AMACR.
Variable degree of AMACR staining was seen in the prostatic carcinoma, which served as a positive control and a benign case was used as a negative control.
Results of immunohistochemical staining Immunostain Result Bcl2 Negative c-erbB2 Negative (1+) Cyclin D1 Positive EGFR Positive (2+) Ki-67 60% P53 Positive AMACR Negative CK-7 Negative CK-20 Positive CDX-2 Positive TTF-1 Negative
The positive AMACR staining was described by continuous, dark red cytoplasmic staining or apical granular staining patterns in the malignant epithelial cells that could be observed easily at low-power magnification (<100x), whereas 34[beta]E12 and p63 were considered positive by dark brown cytoplasmic and nuclear staining in the basal cells respectively.
Immunohistochemical staining on FNA cell block preparations showed positive staining for E-Cadherin, CD10 (Figure 4), AMACR (Figure 5), and cytokeratin AE1/AE3.
7 AMACR is overexpressed in premalignant and malignant le- sions of the prostate compared within the normal prostate.
ise AMACR 'negatif' oldugunu dolayisiyla AMACR pozitifliginin karsinomatoz degisimin erken temsilcisi olabilecegini belirtmislerdir.
5) When dealing with tumors with clear cell features and morphology not typical for clear cell RCC or when limited material is available, we usually perform a panel of markers in various combinations that includes CA-IX, CK7, AMACR, CD117, transcription factor E3 and transcription factor EB (TFE3/TFEB), and HMB45.
Tumour cells demonstrated immunopositivity for pancytokeratin, vimentin, CD10, CK19 and AMACR (Fig.
For this study, the research team looked at the actions of the AMACR gene in human tissue.
AMACR (a methylacyl-CoA racemase) (12), HPN [hepsin (transmembrane protease, serine 1)] (13), and ZWINT (ZW10 interactor) (14) are all associated with prostate cancer in the scientific literature but are known to not be secreted and were correctly identified as such by our methods.