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AMACRAlpha-Methylacyl-CoA Racemase
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Immunohistochemical staining on the cell block showed the tumour cells to be positive for TTF-1 (Figure 2b), Napsin A (Figure 2c) and negative for Thyroglobulin, CD10, PAX8, AMACR, CA19-9 and CD57 (Figure 2d).
A missense mutation was found in exon 1 of the AMACR gene at p.Gly175Asp position.
It is usually positive for Cytokeratin 7 and P504S (AMACR) immunostains which were also positive in our case; however, due to the location of the tumor, the diagnosis of Papillary RCC was considered unlikely.
Mean and Standard deviation were calculated for quantitative variables like patient's age and frequencies along with percentages were calculated for qualitative variables like AMACR expression.
The tumour cells were positive for CK7 and CK20 (figure 2A and B) and negative for CDX2, PSA and AMACR. Hence, a final diagnosis of urothelial carcinoma, micropapillary variant with adeno and squamoid differentiation of high-grade, muscle-invasive stage (pT2HGUC) was given.
Variable degree of AMACR staining was seen in the prostatic carcinoma, which served as a positive control and a benign case was used as a negative control.
A cocktail of the three antibodies was prepared: a mouse monoclonal antibody (34[beta]E12, Dako) at a dilution of 1:50 was mixed with mouse monoclonal antibody, p63 (NeoMarkers, Fremont, CA) and rabbit monoclonal antibody AMACR (P504S, Corixa, Seattle, WA), each at a 0.5[micro]g/mL dilution.
(vi) Nephrogenic adenomas are typically positive with cytokeratin 7 (CK7), a-methylacyl-CoA racemase (AMACR), P504S, PAX2, and epithelial membrane antigen and are usually negative with p63 [6, 18] (Figures 3(e) and 3(f)).
It also provides a comprehensive reference about the utility of multiple prostate markers and their limitations, including AMACR (Clone 13H4) and Prostein (Clone 10E3), among others.
Immunohistochemical staining with triple stain PIN4 cocktail comprising of alpha-methylacyl-CoA racemase (AMACR), p63, and CK 5/6 confirmed areas of PCa and delineated the normal prostate glands.
The aim of this study was to investigate the expression patterns of AMACR and iNOS in prostate adenocarcinomas with different histopathologic grade.