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To establish the diagnosis of the male AMFB in our case, a variety of benign and malignant myxoid soft-tissue neoplasms needed to be ruled out.
Aggressive angiomyxoma and AMFB have been established as unusual angiomyxoid neoplasms of the female vulvovaginal tract that constitute distinct clinical and pathologic entities.
The histologic features of AMFB vary considerably among the cases characterized by alternative hypocellular and hypercellular areas, showing considerable variation in cellular morphology and displaying spindle, satellite, oval or epithelioid cells, and occasional polymorphic cells, as shown in the present case.
However, much controversy exists among recent reports regarding the immunophenotypes of AMFB and AAM.