AMPD3Adenosine Monophosphate Deaminase 3
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Variable importance in projection (VIP) analysis identified genes involved in nucleotide degradation (PNP, AMPD3) and lipid metabolism (ETNK1, HMGCS1) as top classifiers in IFN-[alpha] stimulation in BMM.
Four phosphodiesterases (PDE4D, PDE7A, PDE7B, and PDE8B) and two adenylate cyclases (ADCY2, ADCY4) were upregulated, and adenylate kinase (ADK) and AMP deaminase 3 (AMPD3) were downregulated in stimulated versus unstimulated cells.
Calcium activates erythrocyte AMP deaminase [isoform E (AMPD3)] through a protein-protein interaction between calmodulin and the N-terminal domain of the AMPD3 polypeptide.