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Studies were excluded if they met the following criteria: (1) randomized crossover trials, case reports, reviews, qualitative studies, or animal experiments; (2) the studies which did not contain the effectiveness comparison between experiment group and the control group for treating ANFH; (3) participants receiving treatment which were CD combined with other treatments (e.g., Tantalum rod, vascularized pedicle bone flap) or transplantation of stem cells not derived from bone marrow.
Participants were diagnosed with ANFH stage via three different criteria: the ARCO diagnostic criteria were used in nine studies [30-34, 36, 38-40], the Ficat diagnostic criteria were used in one study [35], and the Steinberg diagnostic criteria were used in one study [37].
In a word, safety of CDBMSCs for ANFH is acceptable.
These findings promoted researchers to develop a new approach for the treatment of ANFH, based on combination with core decompression implantation BMSCs into the necrotic zone of the femoral head.
We selected acellular bone with a trabecular bone structure as the scaffold and ECM as the cartilage to prepare an osteochondral biphasic scaffold seeded with BM-MSCs for repairing ANFH and a large area of osteochondral defects.
A bionic scaffold with suitable mechanical strength and good degradation rate according to the trabecular microstructure of high-load-bearing area combined with vascular technology will improve the effectiveness of restoration and provide a new choice for ANFH and large osteochondral defects of the femoral head.
A 30-year-old woman (IV[sub]6) from the southern region of Henan Province of China came to our institution for genetic consulting when she was pregnant because she was diagnosed with ANFH at 26 years of age and six other members of her family had ANFH.
Individuals II[sub]5, III[sub]2, III[sub]4, IV[sub]2, IV[sub]7, and IV[sub]8 were diagnosed with ANFH at 83, 54, 50, 31, 19, and 19 years of age, respectively.
The heterozygous mutation of COMP was co-segregated with phenotype in this family, indicating that the diagnosis of this family's disease should be MED rather than ANFH.
[sup][20] The condition of fracture healing, ANFH and the function recovery of the affected hip were periodically followed.
ANFH occurred in 9 patients (29.1%) in Group A and 2 patients (6.7%) in Group B.
Different from femoral neck fractures in elderly patients, because of strong external force with severe damaging of medial femoral circumflex artery and lateral femoral circumflex artery, young adults are more likely to develop to nonunion and ANFH. [sup][9],[10],[11] Foveolar artery is barely injured, but only small area blood supply cannot prevent it.