ANKLAggressive Natural Killer-Cell Leukemia
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In comparison, ANKL is characterized by the presence of circulating neoplastic NK cells, with a range of appearances from cells that are slightly larger than large granular lymphocytes to cells with irregular nuclear contour, enlarged nuclei, immature chromatin pattern, and prominent nucleoli.
With the exception of lacking surface CD3 expression, ANKL cases can show an immunophenotype that is almost identical to that of HSTCL.
The circulating neoplastic cells of this case were blastlike with large irregular nuclear contour and contained scant azurophilic granules, findings commonly seen in ANKL.