cytidine deaminase mutagenesis pattern is widespread in human cancers," Nature Genetics, vol.
Access to the nucleus by APOBEC
family members likely permits DNA deamination activity that introduces mutations and genomic instability during tumourigenesis.
TNF (factores de necrosis tumoral)-[alpha] y -[gamma], [alpha]-defensina-1, CAF (factor antiviral derivado de LT CD8), TRIM (motivo tripartito)-5[alpha], APOBEC
(apolipoproteina B, editor enzimatico de RNA y catalitico de polipeptidos)-3G.
The change appeared to be linked to increased activity of a common enzyme named APOBEC
, they theorised.
family of genes control enzymes that are believed to have evolved in humans to fight off viral infections.
Among these gene families, the APOBEC
gene family in the monotocous specific gene set, and Gm6214 and Zcchc10 families in the polytocous specific gene sets showed <50% identity and <50% coverage, indicating that they do not exist in the counterpart groups.
The proteins, known as APOBEC
cytidine deaminases, cause clusters of mutations that can outnumber all others associated with cancer, say the researchers.
The homo neanderthalis have the APOBEC
phenotype which makes them resistant to retroviral infections and the HERV load in the Neanderthal genome is less.
Oncologists, geneticists, and biochemists from the US and Europe explore such aspects of the current field as the regulation of ion channel and transporter function through RNA editing, the coordination of RNA editing with RNA processes in kinotoplastic mitochondria, RNA editing and small regulatory RNAs, deaminase-dependent and deaminase-independent functions of APOBEC
1 and its complementation factor in the context of the APOBEC
family, and ADAR and the balance game between virus infection and innate immune cell response.
Restriction of foamy viruses by APOBEC
and Vif: APOBEC
is a family of proteins produced by the body that help to protect it against certain viruses.
The research conducted by the National Institutes of Health has found that APOBEC
mutations can outnumber all other mutations in some cancers, accounting for over two-thirds in some bladder, cervical, breast, head and neck, and lung tumors.