APQ4Aquaporin4 (membrane channel protein found in brain, retina, kidney & other areas)
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In our study, Ang1 infusion into the blood vessels may reduce the amount of NMO-IgG diffused into the CNS and alleviate its attack on APQ4 on astrocytes, whose plasma membranes surround blood vessels.
Although the pathogenesis of MS and NMO as well as the expression patterns of APQ4 and GFAP in these two diseases is quite different [2, 37], these two distinct diseases share common processes, including BBB disruption, activation of chemotactic factors, and extensive infiltration of inflammatory cells.
Caption: Figure 2: C + A treatment reversed the loss of APQ4 within the optic nerve and spinal cord.