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A non-significant (p = 0.06) improvement was observed in the aPWV for the nitrate group after intervention, which trended towards improvement compared to the placebo group.
The primary objective of the study is to evaluate the effect of an experimental inhalation therapy administered once daily (QD) compared with placebo on aPWV in subjects with COPD and aPWV ≥ 11.0 m/s at baseline.
Epidemiological studies using these measures have determined that high aortic pulse wave velocity (aPWV) is an independent predictor of arterial stiffness and cardiovascular disease and death.
aPWV (cm/s)###8.910.12###8.780.09###15.73###less than 0.001
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- APX homolog of Xenopus
- APX III