AQP1Aquaporin1 (major water channel of red blood cells)
AQP1Aquaporin1 (membrane channel protein found in red blood cells and numerous tissues)
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AQP1 is expressed at several sites that are potentially involved in dietary fat processing, including intrahepatic cholangiocytes (bile secretion) (Ma et al.).
Human articular chondrocytes, synoviocytes and synovial microvessels express aquaporin water channels; upregulation of AQP1 in rheumatoid arthritis.
2D = grown on plastic, 2.5D = grown on transwell inserts, 3D = grown in matrigel sandwich, OAT = organic anion transporter, MRP = multidrug resistance protein, OCT = organic cation transporter, CTR1 = copper transporter 1, MATE = multidrug and toxin extrusion protein, OCTN = organic cation/ carnitine transporter, PGP = multidrug resistance protein/[gamma]-glycoprotein, BCRP = breast cancer resistance protein, SGLT = sodium/glucose co-transporter, GLUT1 = glucose transporter 1, CUBN = cubilin, AQP1 = aquaporin 1, GGT1 = y-glutamyltransferase 1, ALPL = alkaline phosphatase, LAP3 = leucine aminopeptidase 3, BF = bright field, RFU = relative fluorescence unit.
On the basis of this evidence, in this work, we analyzed the urinary excretion of AQP1, AQP2, and AQP5 in three groups of patients: 12 diabetic with no sign of nephropathy (DM), 12 diabetic with histologic diagnosis of diabetic nephropathy (DN), and 11 diabetic with nondiabetic nephropathy (NDN).
E-cadherin and cytokeratin 18 (CK18) are markers of mature epithelial cells; K- cadherin (CDH6) is an early marker of epithelial commitment of nephron progenitors; aquaporin 1 (Aqp1) and osteopontin (OPN) are a marker of renal tubule epithelia cells [23-26].
Liu et al., "Gene expression of AQP1, AQP5 in Sjogren's syndrome model mice salivary gland, and the therapeutic effect of jiedu huayu herbs," New Journal of Traditional Chinese Medicine, vol.
The first AQP protein, named CHIP28 or AQP1, was isolated from human red blood cell in 1988 (Denker et al., 1988); its function as membrane water channel in Xenopus laevis oocytes was confirmed in 1992 (Preston et al., 1992).
mRNA expression levels of TNF-[alpha], IL-4, IL-5, Aquaporin-1 (AQP1), and AQP5 were evaluated using reverse transcription polymerase chain reaction (RT-PCR) followed by gel electrophoresis.
(2016) Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung.
Apart from water and glycerol, various channels permeate a number of other compounds, such as N[H.sub.3] and C[O.sub.2], through AQP1, AQP4, and AQP5 in mammals, or ammonium and/or methylammonium transport B (AmtB) in bacteria (Musa-Aziz et al., 2008; Finn and Cerda, 2015); and [H.sub.2][O.sub.2], through some members of plasma membrane intrinsic proteins (PIPs), Nodulin 26-like intrinsic proteins (NIPs), X-intrinsic proteins (XIPs), and tonoplast intrinsic proteins (TIPs) in plants (Bienert et al., 2007; Bienert and Chaumont, 2014).
For example, AQP1 molecules are expressed in many cells and tissues and maintain homeostasis.
Results showed AQP4 and glial fibrillary acidic protein were overexpressed, especially near the ventricles, but expression of AQP1 was decreased.