AQP2

AcronymDefinition
AQP2Aquaporin2 (membrane channel proteins found in cells of the kidney collecting duct)
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References in periodicals archive ?
Lithium-induced reduction in urinary concentrating ability and urinary aquaporin 2 (AQP2) excretion in healthy volunteers.
Congenital nephrogenic DI (CNDI) is an inherited form of NDI and this disorder occurs as a result of loss-of-function mutations of the AVPR2 or AQP2 genes.
In this study, we investigated the effects of ROS, SR1664, and TNF[alpha] (increased phosphorylation of PPAR[gamma]) on p-PPAR[gamma], AQP2, and [alpha]ENaC in HEK293 and mIMCD-3 cells, being then coincubated with PPAR[gamma] antagonist GW9662; results showed that the effects disappeared.
On the basis of this evidence, in this work, we analyzed the urinary excretion of AQP1, AQP2, and AQP5 in three groups of patients: 12 diabetic with no sign of nephropathy (DM), 12 diabetic with histologic diagnosis of diabetic nephropathy (DN), and 11 diabetic with nondiabetic nephropathy (NDN).
Abbreviations AQP2: Aquaporin 2 CNIs: Calcineurin inhibitors NKCC2: [Na.sup.+]-[K.sup.+] -2[Cl.sup.-]-cotransporter ICU: Pediatric intensive care unit PRSL: Potential renal solute load RTA: Renal tubular acidosis.
Nielsen, "Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP2 water channel in rat kidney," American Journal of Physiology--Renal Fluid and Electrolyte Physiology, vol.
In contrast, diabetes upregulated AQP2 and AQP3 expressions significantly in kidney compared with control group.
Recent studies of 29 actinopterygian and 90 sarcopterygian genomes revealed that the AQP2, -5, or -6 gene clusters represent a genomic apomorphy since they are only found in the lobe-finned fish lineage (Sarcopterygii), including tetrapods that secondarily adapted to the aquatic environment (Cerda and Finn, 2010; Tingaud-Sequeira et al., 2010; Finn and Cerda, 2011; Xu et al., 2013; Finn et al., 2014).
showed that treatment with an [AT.sub.1]-recptor antagonist partially prevented the acute ureteral obstruction-induced downregulation in [Na.sup.+]-phosphate cotransporter type-2 (NaPi-2) at the proximal tubule, [Na.sup.+]-[K.sup.+]-2[Cl.sup.-] cotransporter type-2 (NKCC2) at the thick ascending limb, AQP2 at the collecting duct and attenuated the reduction in [Na.sup.+] and water reabsorption.
Recent reports dealing with AQPs, nitric oxide synthase (NOS isoforms) and water permeability show that an NO-mediated pathway results in the insertion of AQP2 from the cytoplasm into the plasma membrane in the kidney.[sup.14,15] It has been suggested that NO could modify plasma membrane proteins, such as AQP1, and interfere with their function.
Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress.
P catabolitos proteicos) hiperal dosteronismo hiperosmolalidad tubular (K) hipoadrenocorticismo * hiperosmolalidad tubular (urea, Na, Cl) hiperadrenocorticismo inhibicion de secrecion y acciones de ADH hiperparatiroidismo ** hipercalcemia ([flecha superior] osmolalidad plasma, estimulacion sed, inhibicion ADH) diabetes ausencia / deficiencia de ADH insipida hipofisaria diabetes falla receptores tubulares de ADH insipida nefrogenica (acuaporina AQP2) poliuria psicogenica psicopatia (no confundir con polidipsia causada por fiebre y dolor) piometra falla receptores tubulares de ADH por toxinas bacterianas (E.