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Regulation of collecting duct AQP3 expression: Response to mineralocorticoid.
The targeted mRNAs of has-miR-429 and has-miR-5088, DPP4, SERPING1, and AQP3 were validated to be downregulated in the new RIF samples in our previous report.
Studies also showed that the expression of AQPs changed in the gastrointestinal tract of rats with the DSSD syndrome, including AQP1, AQP2, AQP3, and AQP4 [20,25,26].
As shown in Figure 4(a), compared to untreated control, HSEE treatment increased AQP3 and FLG expression by 20% and 60%, respectively.
Moreover, CAV1, CD200R1, HRASLS2, MIA, TNFRSF17, CXCR3, and AQP3 among the top twenty upregulated genes as well as EIF1AY, DDX3Y UTY, IL7R, and CD3D among the top twenty downregulated genes are involved in immune function of organism.
Aquaporin 3 (AQP3) is the most abundant aquaglyceroporin in human epidermis, being responsible for facilitating the transportation of water, glycerol and other solutes like urea through membranes.
AQP2 was expressed throughout the cytoplasm of the epithelium and detrusor muscle layer, whereas AQP3 was expressed throughout the cell membrane of the urothelium and not in the cell cytoplasm (Fig.
Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) comprise a subfamily of aquaporins.
Several biologically plausible genes (Hernandez and Marcos 2008) were located in those areas, including three histone methyltransferases [PR domain zinc finger protein 9 (PRDM9) on chromosome 5, histone methyltransferase EHMT1 on chromosome 9, and ribosome RNA-processing protein 8 (RRP8) on chromosome 11] and one aquaglyceroporin, aquaglyceropin 3 (AQP3) on chromosome 9.
Our analysis revealed that AQP0, AQP1 and AQP3 were expressed in over 100 tissues.
Such rapid reabsorption in the PCT and descending loop of Henle is facilitated by a high density of AQP1 and AQP3 (Figure 3A).
AQP3, AQP7 y AQP9 son acuagliceroproteinas, las demas se consideran acuaporinas clasicas.
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