For example, both AQP1 and AQP5 are observed in pancreatic ducts.
In the alveolus, AQP1 was identified in the endothelial cells, and AQP5 was identified in the membranes of Type I pneumocytes (as shown in Figure 2).
As described above, AQP5 contains a phosphorylation sequence homologous to the regulatory portion of AQP2.
59) Interestingly, AQP5 was transiently up-regulated upon reoxygenation, while expression of the other AQPs returned to normal.
A similar on/off mechanism is thought to control AQP5 function in secretory glands, such as salivary and lacrimal glands.
Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP 1, AQP3, AQP4, and AQP5.
Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.