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Based on the methodology used to establish the inferred network of MYBARNT2, the most relevant tumor suppressive activities of this network are determined mainly from the 1/10th tumor sample group that has relatively high mRNA levels of both MYB and ARNT2 in a given cohort to contribute the highest subCID value based on CID subgrouping strategy .
Additionally, MYB is an estrogen responsive gene  and ARNT2 is a xenoestrogen responsive gene .
The most interesting finding is the inferred target genes of both MYB and ARNT2 including POU2F1, SALL2, and XBP1.
Second, a supervised network analysis has identified a potential prognostic relevant signature of MYB and ARNT2 (i.e., 41gene signature).
We suspect that both univariate and multivariate COX proportional hazard (COXPH) analyses for this signature show not significant (Table S5.4) due to the unique regulatory mechanisms of MYB in coupling with ARNT2 and the small N number for those tested cohorts.
As a result, this is the first time it was reported that MYBL1 and MYBL2 may partially antagonize the action of 24 probes in the favorable prognosis signature that are predicted to be regulated by MYB and ARNT2 (Table 2 and Figure 7).
There are forty-one probes as the inferred target genes of MYB and ARNT2. MYB may actively suppress oncogenic activities of NFKBIL2 , GAPDH , RAB42 , EIF5A , and PICK1 .
This indicates the major clinical impact of both MYB and ARNT2 to be tumor suppressive during early tumor development.
Silencing both MYB and ARNT2 in 90 IDCs reveals an increase in expression levels of some unfavorable prognostic predictors.
Ema et al., "cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)," Molecular and Cellular Biology, vol.
Murray, "Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts," Teratology, vol.
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