Patients with ARVC
must be restricted from participation in competitive sports, a step whose importance was demonstrated in the North American Multidisciplinary Study of ARVC
, for which Dr.
Our patient has definite ARVC
going by the revised task force criteria, meeting major criteria for echocardiographic changes and electrocardiogram repolarisation abnormalities.
is a genetic form of cardiomyopathy characterized by fibrofatty replacement of predominantly right ventricular (RV) myocardium and is one of the leading causes of sudden unexpected cardiac death in young, apparently healthy individuals.[sup] As disease progresses, RV dilation and RV dysfunction may occur.
The diagnosis of ARVC
requires the identification of major and minor criteria laid down by the working group on myocardial and pericardial diseases of the European Society of Cardiology in 1994, which was revised in 2010 [Table 1].
prevalence in general population is variable, with ranges from 1: 2 000 to 1: 5 000, with a special mention that some of these values may be even larger .
Studies in humans with ARVC
identified that affected patients with lower HRV parameters are more prone to arrhythmic events (BATTIPAGLIA et al., 2012).
Inhibition of Wnt/beta-catenin signaling and upregulation of PPAR gamma have been reported in ARVC
The analysis of downregulated miRNAs regulated by exercise revealed that Fatty acid elongation pathway and Arrhythmogenic right ventricular cardiomyopathy (ARVC
) pathway could be associated with the hypertrophy process.
The former England Test batsman, who announced his retirement last week, spent a fortnight in hospital where - his club Nottinghamshire confirmed - he underwent a "preliminary procedure" to aid his recovery from arrhythmogenic right ventricular cardiomyopathy (ARVC
The Nottinghamshire batsman (above) has been forced to call time on his career after being diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC
) - the same condition which caused the retirement and near-death of Bolton footballer Fabrice Muamba in 2012.
However, scans revealed he has a serious heart condition known as Arrhythmogenic Right Ventricular Arrhythmia (ARVC
A family history of sudden cardiac death or syncope should be sought when a familial cause is suspected (torsade de pointes with the congenital long QT syndrome and VT or PVCs with arrhythmogenic right ventricular cardiomyopathy (ARVC